Ursodeoxycholic acid-induced choleresis in isolated rat liver perfusion.
نویسندگان
چکیده
منابع مشابه
Pre-replicative phase-related changes in bile acid-induced choleresis in the regenerating rat liver.
1. During the pre-replicative phase of the regenerating rat liver some interesting changes occur, which might selectively modify some mechanisms involved in bile formation, such as those responsible for the hypercholeretic effect of ursodeoxycholic acid. The aim of the present work was to gain information on this point. 2. Anaesthetized male Wistar rats (approximately 250 g) were used. The anim...
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The isolated perfused rat liver (IPRL) has proven to be a useful model for the study qf physiology and pathology of the liver, For research in nonparenchymal cell (NPC) function that includes measurement of cytokine production (eg, TNF), it is necessary to have a sterilized perfusion system, We have modified the IPRL apparatus so as to be able to perform sterile perfusions of two livers simulta...
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BACKGROUND/AIMS Cysteinyl-containing leukotrienes seem to exert a cholestatic effect. However, leukotriene inhibitors were found to reduce bile salt efflux in isolated rat hepatocytes, suggesting a role for leukotrienes in bile flow formation. METHODS In the isolated rat liver, the effects of two different concentrations of leukotriene C4 on bile flow and bile salt excretion are analyzed, as ...
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Background: Corn silk (CS) is widely used in Iranian traditional medicine. The aim of this study was to investigate hepatoprotective activity of CS by Isolated Rat Liver Perfusion System (IRLP). Methods: Hydro-alcoholic extract of corn silk (10, 20, 40, and 100 mg kg-1) was evaluated for its hepatoprotective activity by IRLP. Phenol and flavonoid contents of the extract were determined as gal...
متن کاملUrsodeoxycholic acid in chronic liver disease.
The hydrophilic bile acid ursodeoxycholic acid has recently been shown to reduce biochemical markers of both cholestasis and hepatocellular damage in patients with chronic liver diseases. The most compelling evidence available is for chronic cholestatic liver diseases, in particular primary biliary cirrhosis, primary sclerosing cholangitis, and cholestasis associated with cystic fibrosis. The e...
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ژورنال
عنوان ژورنال: Kanzo
سال: 1987
ISSN: 0451-4203,1881-3593
DOI: 10.2957/kanzo.28.1098